Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
POU class 6 homeobox 2 (POU6F2)
- Target
- POU6F2
- Molecular classification
- Transcription factor, Homeobox protein
01
Overview
POU class 6 homeobox 2 (POU6F2) is a transcription factor belonging to the POU protein family, characterized by a bipartite DNA-binding domain (POU-specific and homeodomain) that modulates gene expression through binding DNA as monomers or dimers in a sequence-specific manner. It participates in cell-type-specific differentiation pathways, particularly within neural and retinal development, and acts as a tumor suppressor associated with Wilms tumor susceptibility. Variants in POU6F2 have been implicated in disruption of gonadotropin-releasing hormone (GnRH) neuronal regulation, contributing to disorders like idiopathic hypogonadotropic hypogonadism and affecting reproductive development. Multiple isoforms exist due to alternative splicing, and their activity may involve both gene activation and repression[1][2][3].
- Other names
- WTSLWT5RPF-1RPF1Retina-derived POU domain factor 1Retina-derived POU-domain factor-1Wilms tumor suppressor locus
02
Biological functions
DNA bindingTranscriptional regulationCell differentiation (especially in neural and ocular tissues)Negative regulation of GnRH1 gene expressionTumor suppressor activity
03
Disease associations
Cancer (notably Wilms tumor predisposition)Hypogonadotropic hypogonadism (IHH)Disorders of pubertal development
Beyond the preview
Go deeper on POU class 6 homeobox 2 (POU6F2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on POU class 6 homeobox 2 (POU6F2).