POU3F3 adjacent non-coding transcript 1 (PANTR1)

POU3F3 adjacent non-coding transcript 1 (PANTR1) is a long non-coding RNA gene (lncRNA), highly conserved between human and mouse, which modulates the site-specific chromatin binding of transcription factors such as FOXG1 and NEUROD1 during neuronal development. PANTR1 is transcriptionally regulated by FOXG1 and, in turn, governs FOXG1’s localization at select genome regions, thereby influencing the epigenetic landscape and neuronal differentiation. Although synonyms suggest possible relevance in cancer, its best-documented and canonical role is as a neural regulator, contributing mechanistically to FOXG1-syndrome and neuronal outgrowth. There are no drugs or small molecules known to target PANTR1 directly, and it is not considered a classical "therapeutic target" but rather a biological modulator of cell phenotype.

Other names

LINC-BRN1ALINC-POU3F3LINC01114LINC01158linc-Brn1alinc-POU3F3long intergenic non-protein coding RNA 1114long intergenic non-protein coding RNA 1158PANTR1PANCATpancreatic cancer associated transcript

not applicable