PPAN-P2RY11 readthrough protein (PPAN-P2RY11)

The PPAN-P2RY11 readthrough gene represents a naturally occurring fusion transcript between the upstream PPAN (Peter Pan homolog) gene, which encodes a ribosome biogenesis factor, and the P2RY11 (P2Y purinoceptor 11) gene, which encodes a G protein-coupled receptor responsive to extracellular nucleotides[1][4]. This readthrough transcript encodes a fusion protein sharing sequence with both gene products. The mRNA is ubiquitously expressed and may be upregulated by agents that induce granulocytic differentiation[1][4]. Currently, the biological function and therapeutic relevance of the PPAN-P2RY11 fusion protein itself is unclear, and it is not established as an independent functional protein or drug target[4].\n\nImportant context: While *P2Y purinoceptor 11* (*P2RY11*) is a well-characterized therapeutic target implicated in immune regulation and inflammation and is classified as a G protein-coupled receptor[1][2], the *PPAN-P2RY11 readthrough protein* is a fusion product with no clearly defined or clinically validated function independent of its components[4]. It should not be conflated with P2Y11 receptor itself for drug targeting or disease role unless further research emerges.\n\nSummary on accuracy: The target as described is not a recognized therapeutic target; the readthrough/fusion product is of uncertain biological or therapeutic relevance and is primarily of academic interest at this time[4]. For structured data resources or drug discovery, the primary targets of interest are usually the individual, canonical P2Y purinoceptor 11 or Peter Pan homolog (PPAN) proteins.

Other names

BXDC3P2RY11P2Y11PPANSSF1Ssf-1PPAN-P2RY11 proteinBrix domain-containing protein 3P2Y purinoceptor 11Peter Pan homologSSF1/P2Y11 proteinSuppressor of SWI4 1 homologPPAN-P2RY11 readthrough transcript

Not established for the fusion. Agonism of G protein-coupled receptor activity (if the P2Y11 domain is functional)[2]