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Target intelligence / Profile preview
PPFIA2 antisense RNA 1 (PPFIA2-AS1)
- Target
- PPFIA2-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Other
01
Overview
PPFIA2 antisense RNA 1 (PPFIA2-AS1) is a long non-coding RNA gene located on human chromosome 12 (chr12:81270669-81312422, hg38). It is transcribed antisense to the PPFIA2 protein-coding gene, which plays a role in synaptic organization in the nervous system. PPFIA2-AS1 is strongly implicated in regulating the expression of PPFIA2, consistent with the broader role of antisense RNAs in modulating gene expression through various mechanisms, including transcriptional interference and epigenetic modification. As a lncRNA, PPFIA2-AS1 does not encode a protein and is not a receptor, enzyme, or transporter, nor is it currently known to be a direct drug target or biomarker. The functional annotation of PPFIA2-AS1 remains primarily centered on its possible regulatory impact on PPFIA2 and related synaptic processes, in line with general properties of antisense RNAs.
- Other names
- PPFIA2-AS1PPFIA2 antisense RNA 1ENSG00000257467NCBI Gene 102724663
02
Mechanism of action
Not applicable
03
Biological functions
Regulation of gene expression (antisense regulation of PPFIA2, which is involved in synaptic organization)Potential chromatin modification and epigenetic regulation (general function of antisense RNAs, supported by analogous lncRNAs)
04
Disease associations
Other (No direct disease association found for PPFIA2-AS1; the sense gene PPFIA2 is linked to neurological disorders and synaptic function)
05
Safety considerations
None
06
Interacting drugs
None
07
Biomarkers
None
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