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PPFIA2 antisense RNA 2 (PPFIA2-AS2)

Target: PPFIA2-AS2
Molecular classification: Non-coding RNA, Antisense RNA

Overview

PPFIA2 antisense RNA 2 (PPFIA2-AS2) is a human non-coding antisense RNA gene located opposite the PPFIA2 locus, with as-yet-undescribed function or disease relevance.

Mechanism of action

Theoretical: Inhibition of antisense transcript to modulate sense gene expression

Biological functions

Regulation of gene expression (inferred from family of antisense RNAs)No specific biological function identified for PPFIA2-AS2

Disease associations

Antisense RNA deregulation implicated in cancer and other diseases in generalNo specific disease associations reported for PPFIA2-AS2

Safety considerations

Off-target effectsImmune stimulation (e.g., by modified oligonucleotides)Toxicity from chemical modifications used to stabilize oligonucleotides

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