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Target intelligence / Profile preview
PPP1R26 antisense RNA 1 (PPP1R26-AS1)
- Target
- PPP1R26-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Other
01
Overview
PPP1R26 antisense RNA 1 (PPP1R26-AS1) is a human long non-coding RNA (lncRNA) gene classified as antisense to PPP1R26 (Protein phosphatase 1 regulatory subunit 26). PPP1R26-AS1 is implicated in the regulation of gene expression via non-coding RNA mechanisms, particularly by acting as a competing endogenous RNA (ceRNA), interacting with microRNAs such as miR-1226-3p. Elevated levels of PPP1R26-AS1 have been observed in breast cancer tissues and are associated with increased migration, invasion, and proliferation of tumor cells, indicating a potential role in cancer progression and prognosis. However, it is not a protein-coding gene, receptor, enzyme, or typical therapeutic drug target; rather, its significance is primarily in gene regulation and potential biomarker applications[1][4][5].
- Other names
- PPP1R26-AS1
02
Biological functions
Regulation of gene expressionCompeting endogenous RNA (ceRNA) activityTumor cell migration and invasionCell proliferation
03
Disease associations
CancerBreast cancer
04
Biomarkers
Overexpression associated with poor prognosis in breast cancer
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