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PPP2R1A antisense RNA 1 (PPP2R1A-AS1) is an antisense long non-coding RNA located opposite the PPP2R1A gene locus. While other antisense lncRNAs can regulate the transcription, stability, or translation of their corresponding sense genes, there is no published evidence on the specific biological activity, disease association, or druggability of PPP2R1A-AS1[6]. Most functional and therapeutic research focuses on the protein-coding PPP2R1A gene, which encodes a major scaffold subunit of protein phosphatase 2A (PP2A), a critical regulator of cell signaling and a recognized therapeutic target in oncology and neurodevelopmental diseases[1][3][4].
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