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PR domain-containing protein 7 (PRDM7)
- Target
- PRDM7
- Molecular classification
- Enzyme (specifically, histone methyltransferase), Epigenetic modifier, Zinc finger protein
01
Overview
PR domain-containing protein 7 (PRDM7) is a primate-specific histone methyltransferase that catalyzes the trimethylation of lysine 4 on histone H3 (H3K4me3) in vitro and in cells, defining an active chromatin state and playing a role in epigenetic regulation of gene expression. It contains a KRAB (Kruppel-associated box) domain, a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain, and one or more zinc fingers. PRDM7 resulted from a recent gene duplication of PRDM9 and is primarily expressed in testis and melanocytes, though its full biological roles and implications in disease are not yet fully elucidated[1][2][3][4][5][6].
- Other names
- Histone-lysine N-methyltransferase PRDM7ZNF910PFM4PR domain zinc finger protein 7PR domain-containing protein 7PR-domain family protein 4PR domain 7
02
Biological functions
Histone methylation (specifically H3K4 trimethylation)Epigenetic regulationTranscriptional regulationNuclear process regulation
03
Disease associations
Cancer (potential role via epigenetic regulation; specific roles still unclear)Other (basic research phase, no definitive disease association yet)
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