PR domain zinc finger protein 10 (PRDM10)

PR domain zinc finger protein 10 (PRDM10) is an epigenetic-regulatory transcription factor belonging to the PRDM family, characterized by an N-terminal PR domain and multiple C2H2 zinc fingers. PRDM10 acts as a sequence-specific DNA-binding protein and transcriptional activator essential for early mammalian development, embryonic stem cell maintenance, and the oocyte-to-embryo transition. It regulates gene expression by binding to gene promoters and recruiting transcriptional coactivators via its PR and glutamine-rich (Q-rich) domains, but, unlike some PRDM family members, it is not an active histone methyltransferase. PRDM10 controls global translation through the regulation of EIF3B, organizes cytoskeletal components in oocytes, and maintains cell homeostasis. Pathologically, PRDM10 is implicated in the formation of specific soft tissue sarcomas through gene fusions and possibly involved in Birt-Hogg-Dube syndrome via its targets such as FLCN. Loss of function is incompatible with early embryogenesis in mice and possibly in humans. There are no known approved drugs directly targeting PRDM10.

Other names

PR/SET domain 10PRDM10KIAA1231PFM7TRISMGC131802PR domain-containing protein 10TristaninPRDM zinc finger transcription factorPR-domain family member 7BHD2

Not applicable (no known small-molecule or biologic drug modulators documented). For fusions (CITED2-PRDM10, MED12-PRDM10): thought to exert oncogenic effects via transcriptional dysregulation in sarcoma.