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Target intelligence / Profile preview
PR domain zinc finger protein 5 (PRDM5)
- Target
- PRDM5
- Molecular classification
- Transcription factor, Zinc finger protein, PR-domain protein family
01
Overview
PR domain zinc finger protein 5 (PRDM5) is a transcription factor containing a PR (PRDI-BF1 and RIZ1 homology) domain and multiple C2H2-type zinc finger motifs. It is part of the PR-domain (PRDM) family of transcriptional regulators that are involved in cell differentiation and tumorigenesis. PRDM5 exerts regulatory control over the expression of extracellular matrix genes, particularly collagens, playing a crucial role in bone formation and maintenance via controlling gene transcription by recruiting or interacting with RNA polymerase II and modulating chromatin structure. Mutations in PRDM5 have been linked to Brittle Cornea Syndrome and alterations in bone tissue development. The protein functions predominantly as a transcriptional activator in osteoblastic cells and is implicated in epigenetic gene regulation by directly binding DNA at regulatory elements[1][3][5].
- Other names
- PR/SET domain 5PRDM5PR domain-containing protein 5PR domain zinc finger protein 5PFM2BCS2PR domain containing 5
02
Biological functions
Regulation of gene transcriptionExtracellular matrix organization (notably collagen gene transcription)Osteogenic differentiationEpigenetic gene regulation
03
Disease associations
Cancer (implicated in tumorigenesis)Brittle Cornea Syndrome (specifically Brittle Cornea Syndrome 2 and 1)Bone development disorders (via effects on osteogenesis)
04
Safety considerations
Loss-of-function variants linked to tissue fragility (brittle cornea, delayed ossification)Potential effects on extracellular matrix integrity
05
Biomarkers
Brittle Cornea Syndrome 2 (caused by mutations in PRDM5)Possibly a cancer biomarker (based on gene family role)
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