PR domain zinc finger protein 8 (PRDM8)

PR domain zinc finger protein 8 (PRDM8) is a transcription factor of the PRDM protein family, characterized by a PR (PRDI-BF1 and RIZ1 homology) domain and multiple C2H2-type zinc finger motifs[2][3]. It is involved in the epigenetic regulation of gene expression by modulating chromatin structure, either through direct or indirect histone methylation[2]. PRDM8 plays a critical role in neuronal cell differentiation and survival in the retina and broader central nervous system, acting as an essential regulator of cell fate during development[1]. Mutations in PRDM8 are linked to neurological disorders, including developmental epileptic encephalopathies. The protein’s dual regulatory role—as either a transcriptional activator or repressor—is context-dependent, and dysregulation has been implicated in cancer and neurodevelopmental disorders[1][2]. PRDM8 is an emerging but not yet widely exploited therapeutic target, with the broader PRDM family subject to ongoing oncology drug discovery efforts.

Other names

PRDM8PR/SET domain 8PR domain-containing protein 8KMT8DPFM5EPM10PR domain 8PR domain zinc finger protein 8

Not applicable; no known therapeutic drugs directly target PRDM8, but inhibition of PR domain or zinc finger function is a theoretical approach[2].