PRAME family member 10 (PRAMEF10)

PRAME family member 10 (PRAMEF10) is a protein-coding gene in the PRAME family, generally considered part of the larger cancer-testis antigen gene group. The protein is predicted (based on sequence homology and bioinformatic Gene Ontology analysis) to function as a ubiquitin-like ligase-substrate adaptor, participating in the proteasome-mediated, ubiquitin-dependent protein catabolic process, and is thought to function primarily in the cytoplasm, possibly as part of the Cul2-RING ubiquitin ligase complex[4][2]. There is weak predicted nuclear retinoic acid receptor binding activity based on gene annotations, but experimental evidence is lacking[4]. Human disease association is limited and primarily based on genomic correlations, not functional or mechanistic studies[4]. No direct evidence supports its role as a therapeutic target, biomarker, or druggable protein. The PRAMEF10 gene is referenced with the NCBI Gene ID 343071 and UniProtKB/Swiss-Prot accession O60809[4]. No substantial experimental literature addresses the specific biological role, structural biology, druggability, or clinical impact of PRAMEF10. Most insights arise from bioinformatic predictions and family-wide analyses; detailed functional or therapeutic information remains unavailable[4][2].

Other names

PRAMEF10PRAME Family Member 10PRA10