PRAME family member 11 (PRAMEF11)

PRAME family member 11 (PRAMEF11) is a protein-coding gene on chromosome 1 (12,824,605–12,831,410, reverse strand), encoding a protein predicted to enable ubiquitin-like ligase-substrate adaptor activity and to participate in proteasome-mediated, ubiquitin-dependent protein catabolic processes as part of a Cullin-2 RING ubiquitin ligase complex[1][9][10]. It is one of the PRAME (Preferentially Expressed Antigen in Melanoma) family members, potentially sharing some characteristics with the broader PRAME family, such as leucine-rich repeats and possible involvement in nuclear receptor signaling, but specific direct biological or therapeutic functions for PRAMEF11 remain unvalidated in the current literature[1][9][10]. There are no known interacting drugs, established biomarkers, or safety concerns documented for PRAMEF11, and it is not currently considered an established therapeutic target.

Other names

PRAMEF11PRAME family member 11Protein PRA11ENSG00000239810UniProt O60813NCBI Gene 440560