PRAME family member 14 (PRAMEF14)

PRAME family member 14 (PRAMEF14) is a protein-coding gene located on chromosome 1 and part of the PRAME (Preferentially Expressed Antigen of Melanoma) gene family[2][6]. While PRAME itself is a well-studied cancer-testis antigen and a validated anti-cancer target in several malignancies, PRAMEF14 is a paralog whose function remains largely uncharacterized. It is predicted to be involved in biological processes such as the negative regulation of apoptotic process, but there is currently no specific published evidence indicating PRAMEF14 itself is a therapeutic target, disease driver, or biomarker in cancer or other pathologies[6]. Most available data concerns the broader PRAME family, and unlike PRAME, PRAMEF14 is not described as a bona fide cancer antigen or actionable therapeutic target[2][6]. No published evidence supports that PRAMEF14 itself is a validated receptor, enzyme, transporter, or therapeutic target[2][6]. Limited data exist on the biological or disease roles of PRAMEF14; information about the PRAME family does not directly equate to this specific family member. Aliases are accurate, but published literature and curated databases such as Ensembl and GDC list only gene/locus information for PRAMEF14, not functional data supporting targetability[2][6]. PRAME family member 14 (PRAMEF14) is a predicted member of the PRAME gene family but lacks adequate functional and clinical characterization to be considered a therapeutic target. Most published roles for PRAME pertain to the canonical PRAME protein, not PRAMEF14[2][6].

Other names

PRAME family member 14PRAMEF14OTTHUMG00000007916