PRAME family member 15 (PRAMEF15)

PRAME family member 15 is a protein-coding gene that belongs to the PRAME (Preferentially Expressed Antigen in Melanoma) family, a group of cancer/testis antigens with roles in immunity, germline development, and oncogenesis[9][1][3]. PRAMEF15 enables ubiquitin-like ligase-substrate adaptor activity and functions as a component of the Cullin2-RING E3 ubiquitin ligase complex, involved in protein ubiquitination and proteasomal degradation[1][3]. Its protein domain structure includes leucine-rich repeats, and it may play a part in regulating retinoic acid signaling and nuclear receptor binding (supported by family member studies)[5][3]. PRAME family members are markers of several cancers and have restricted expression in normal adult tissues, mainly testis, with reactivation in various tumors; PRAMEF15 itself is associated with diseases including adult astrocytic tumor and retinitis pigmentosa[3][9]. Though the direct therapeutic targetability of PRAMEF15 is not established, PRAME family proteins are under investigation as immune targets in oncology due to their high tumor specificity and immunogenicity[9][5]. Note: - There are no current reports of approved drugs directly targeting PRAMEF15 or of biomarker or safety issues specific to this member. - Most biological and potential clinical roles are inferred by analogy to the broader PRAME family, as direct functional and mechanistic data for PRAMEF15 are limited.

Other names

PRAMEF15OTTHUMG00000007921PRAME family member 9/15