PRAME family member 18 (PRAMEF18)

PRAME family member 18 (PRAMEF18) is a protein-coding gene located on chromosome 1 (gene locus: 13,222,695-13,226,154, reverse strand, GRCh38)[2][7]. It belongs to the PRAME (Preferentially Expressed Antigen in Melanoma) family of cancer-testis antigens, a group of proteins generally characterized by their restricted expression in healthy testis and aberrant expression in various tumors[9]. PRAMEF18 shares structural features with PRAME, including multiple leucine-rich repeats (LRRs) that contribute to molecular interactions. According to gene ontology annotations and computational predictions, PRAMEF18 is likely involved in negative regulation of apoptosis and cell differentiation, and may act as an adaptor for ubiquitin ligase complexes in cytoplasmic proteasome-mediated degradation pathways[4][7]. No evidence currently identifies PRAMEF18 as a validated or widely studied therapeutic target, and there are no known drugs or established mechanisms of action targeting this gene. Disease roles are not well defined; the only GeneCards disease association is amebiasis, with no compelling data linking PRAMEF18 directly to pathogenic processes[7]. PRAMEF18 is a poorly characterized member of the PRAME cancer-testis antigen family. It has predicted functions in cell proliferation and protein degradation, but is not validated as a therapeutic target, and its roles in disease remain unclear[2][4][7][9].

Other names

PRAME family member 18PRAMEF18PRAME family member-like