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Target intelligence / Profile preview
PRAME family member 2 (PRAMEF2)
- Target
- PRAMEF2
- Molecular classification
- Other
01
Overview
PRAME family member 2 (PRAMEF2) is a protein-coding gene belonging to the PRAME (Preferentially Expressed Antigen in Melanoma) family, structurally related to other PRAME-like proteins and exhibiting predicted roles in ubiquitin-like ligase-substrate adaptor activity and proteasome-mediated, ubiquitin-dependent protein catabolic processes. PRAMEF2 is postulated to be part of the Cul2-RING ubiquitin ligase complex and is primarily active in the cytoplasm[5]. Its gene is associated with certain muscle diseases, specifically facioscapulohumeral muscular dystrophy types 1 and 2[5]. Unlike canonical members like PRAME itself, there is currently no evidence PRAMEF2 behaves as a therapeutic target, nor that it has a well-established role in cancer, immune response, or as a biomarker for clinical intervention[5][2][4].
- Other names
- FLJ43580DJ845O24.3PRAMEF2
02
Biological functions
Predicted ubiquitin-like ligase-substrate adaptor activityPredicted involvement in proteasome-mediated ubiquitin-dependent protein catabolic process
03
Disease associations
Facioscapulohumeral muscular dystrophy 1Facioscapulohumeral muscular dystrophy 2, digenic
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