PRAME family member 26 (PRAMEF26)

PRAME family member 26 (PRAMEF26) is a human protein-coding gene belonging to the PRAME family, characterized by leucine-rich repeats associated with protein-protein interactions[1][6]. PRAMEF26 is predicted to act as a substrate adaptor within Cullin2-RING E3 ubiquitin ligase complexes, potentially facilitating proteasome-mediated degradation of target proteins in the cytoplasm[2]. Its molecular function and involvement in disease remain largely uncharacterized, and there is no published evidence indicating PRAMEF26's use as a receptor, drug target, or biomarker[2][3][6]. Key distinctions and clarifications: - PRAMEF26 is not the same as PRAME (preferably used for the well-characterized cancer antigen). - PRAMEF26 is a substrate-adaptor protein, not a receptor, enzyme, transporter, channel, or transcription factor[2][6]. - No disease or drug involvement specific to PRAMEF26 is documented. - Nomenclature is correct per standard genomic sources (HGNC; GeneCards; UniProt)[2][6]. If more detailed, structured, or mechanistic biological information is required, future research may be necessary, as current knowledge is limited to predicted roles.

Other names

PRAMEF26PRAMEF25Putative PRAME family member 26