PRAME family member 33 (PRAMEF33)

PRAME family member 33 (PRAMEF33) is a protein-coding gene that is part of the PRAME gene family, which is generally classified as cancer/testis antigens—genes expressed predominantly in the testis and a variety of cancers. PRAMEF33 is predicted to function as a ubiquitin-like ligase-substrate adaptor within the Cul2-RING ubiquitin ligase complex, likely contributing to proteasome-mediated protein degradation processes in the cytoplasm. However, experimental validation of its functional roles is limited, and unlike the canonical PRAME gene, there is no clear evidence that PRAMEF33 is directly involved in tumorigenesis or is targeted by drugs or immunotherapies. Its expression profile, regulatory mechanisms, and pathogenic relevance remain poorly characterized. It has several aliases, some of which arose from previous gene annotation, but "PRAME family member 33" (PRAMEF33) is the standardized designation. As such, PRAMEF33 is not considered a therapeutic target; rather, it represents a member of a broader gene family with potential—but unverified—biological and disease significance.

Other names

PRAMEF33PRAMEF33PPRAME family member 33PRAME family member 10-likePRAME family member 33, pseudogene