PRAME family member 6 (PRAMEF6)

PRAME family member 6 (PRAMEF6) is a human protein that serves as a substrate-recognition component of a Cullin-2 (CUL2)-RING E3 ubiquitin ligase complex (CRL2). This complex mediates the ubiquitination and subsequent proteasomal degradation of specific target proteins, such as truncated selenoproteins produced by failed UGA/Sec decoding. PRAMEF6 belongs to the PRAME (Preferentially expressed antigen in melanoma) gene family, which comprises cancer/testis antigens that are transcriptional regulators, play important roles in germline development, embryonic stem cell pluripotency, and gametogenesis. While PRAMEF6 itself is not a classic drug target such as a receptor or enzyme, it is functionally and structurally relevant in cancer and reproductive biology, and its family is implicated in both tumor immunology and spermatogenesis. Notes: - PRAMEF6's main molecular function is as a component of an E3 ubiquitin ligase complex, making its classification "Other" or "Ubiquitin-proteasome system". - While there is substantial evidence for the PRAME family (but not specifically PRAMEF6) as cancer-testis antigens and therapeutic targets, there is limited/no direct evidence of drugs or inhibitors targeting PRAMEF6 specifically. - As part of the PRAME family, its expression is considered relevant to cancer prognosis and might serve as a biomarker in a broader context, but this is mostly extrapolated from PRAME family data. - No literature-reported safety concerns or patient selection biomarkers specific to PRAMEF6 are currently available based on the provided data.

Other names

PRAMEF6PRAME family member 6PRAM6_HUMAN