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PRAME family member 7 (PRAMEF7)
- Target
- PRAMEF7
- Molecular classification
- Transcription factor (as a member of the PRAME family, which are sometimes nuclear transcriptional regulators), Ubiquitin ligase substrate adaptor (predicted), Leucine-rich repeat protein, Other (gene family: PRAME family)
01
Overview
PRAME family member 7 (PRAMEF7) encodes a protein predicted to function as a substrate adaptor in ubiquitin-like ligase complexes, contributing to proteasome-mediated protein catabolism[5][6]. It belongs to the PRAME gene family, characterized by leucine-rich repeat (LRR) domains that provide structural frameworks for protein-protein interactions, with nuclear localization and transcription-regulatory potential[3][7]. While related PRAME proteins are vital in transcriptional repression (notably retinoic acid signaling), cell differentiation, and germline development, PRAMEF7 itself has not been definitively linked to these functions. Its tissue expression includes various reproductive and neurological tissues, but its precise physiological role and direct involvement in human disease—beyond a limited genetic association with expressive language disorder—are not clearly established[4][5][8].
- Other names
- PRAMEF7PRAME family member 7PRAMEF 7PRAM7_HUMAN (UniProt)ENSG00000204510 (Ensembl)
02
Biological functions
Predicted negative regulation of apoptosisPredicted negative regulation of transcription, DNA-templatedProteasome-mediated ubiquitin-dependent protein catabolic processPossible involvement in stem cell self-renewal and pluripotency (by analogy to murine PRAME family members)Putative nuclear retinoic acid receptor binding
03
Disease associations
Expressive language disorder (GeneCards association)Some PRAME family members are linked to cancer, infertility, and stem cell function, but specific disease associations for PRAMEF7 remain limited or unclear
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