PRC2 and DDX5 associated long noncoding RNA (PRADX)

PRC2 and DDX5 associated long noncoding RNA (PRADX) is a nuclear long noncoding RNA highly expressed in glioblastoma and colon adenocarcinoma tissues. It acts as a cancer driver by recruiting the PRC2/DDX5 complex to chromatin, specifically increasing H3K27me3 at the UBXN1 gene promoter, thereby silencing UBXN1 and activating the NF-κB and STAT3 oncogenic pathways. PRADX is transcriptionally upregulated by the RUNX1-CBFβ complex, is predominantly localized in the cell nucleus, and its knockdown suppresses tumor cell viability and tumorigenesis in preclinical models. High PRADX expression is associated with worse outcomes, particularly in mesenchymal glioblastoma, making it a potential therapeutic target and a biomarker for aggressive tumor subtypes.

Other names

ENST00000449248.1

Recruitment of Polycomb repressive complex 2 (PRC2) and DEAD-box helicase 5 (DDX5) to gene promoters (notably UBXN1), resulting in trimethylation of histone H3 at lysine 27 (H3K27me3) and transcriptional repression. Activation of NF-κB signaling via UBXN1 silencing. Activation of STAT3 pathway via suppression of BLCAP (as shown in glioblastoma models).