Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Pre-B-cell leukemia homeobox protein 1 (PBX1)
- Target
- PBX1
- Molecular classification
- Transcription factor, Homeodomain protein, TALE homeobox protein
01
Overview
Pre-B-cell leukemia homeobox protein 1 (PBX1) is a transcription factor crucial for development, cell differentiation, and proliferation. It functions primarily in hematopoiesis and organogenesis. PBX1 forms heterodimers with other homeobox proteins like HOX and MEIS, regulating gene expression. A key pathological association is the t(1;19)(q23;p13) translocation, resulting in the E2A-PBX1 fusion protein, a driver of pre-B acute lymphoblastic leukemia.
02
Mechanism of action
N/A
03
Biological functions
Developmental regulationHematopoiesisCell fate determinationCell proliferationCell differentiationRegulation of gene expressionApoptosis
04
Disease associations
CancerAcute lymphoblastic leukemia
05
Safety considerations
Potential for off-target effects when targeting PBX1 due to its broad role in development and cellular processes.
06
Biomarkers
E2A-PBX1 fusion transcript (diagnostic marker for ALL)
Beyond the preview
Go deeper on Pre-B-cell leukemia homeobox protein 1 (PBX1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pre-B-cell leukemia homeobox protein 1 (PBX1).