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Pre-mRNA processing factor 31 (PRPF31)

Target: PRPF31
Molecular classification: RNA-binding protein, Splicing factor

Overview

Pre-mRNA processing factor 31 (PRPF31) is a critical component of the spliceosome, the large ribonucleoprotein complex responsible for removing introns from pre-messenger RNA (pre-mRNA) during mRNA splicing. Mutations in PRPF31 cause autosomal dominant retinitis pigmentosa type 11 (RP11), a degenerative retinal disease.

Other names: NY-BR-99PRP31RP11SNRNP61

Biological functions

Spliceosome assemblymRNA splicingU4/U6•U5 tri-snRNP formation

Disease associations

Retinitis pigmentosa type 11 (RP11)

Safety considerations

Essential gene - complete loss-of-function is embryonic lethalTissue-specific effects are not fully understood

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