Pre-mRNA-processing factor 39 (PRPF39)

Pre-mRNA-processing factor 39 (PRPF39) is an evolutionarily conserved, non-enzymatic auxiliary protein component of the spliceosome, primarily involved in pre-mRNA splicing in eukaryotes[1][2][4]. In metazoans, PRPF39 forms a homodimer—acting as a functional replacement for the Prp39/Prp42 heterodimer found in yeast—and is required for efficient spliceosome assembly and alternative splicing[1][2]. PRPF39 regulates alternative splicing by recruiting the U1 small nuclear ribonucleoprotein (snRNP) to weak 5′ splice sites and is essential for the usage of these sites across many cassette exons and introns[4]. Its expression is modulated through alternative splicing events that induce nonsense-mediated mRNA decay, enabling cell- and tissue-specific tuning of splicing efficiency[1][2][4]. PRPF39 expression and alternative splicing patterns impact biological processes linked to development and immune cell differentiation by altering splicing decisions for many mRNAs[1][4]. There are currently no known therapeutic drugs or clinical interventions specifically targeting PRPF39, and it is not considered a canonical therapeutic target (e.g., receptor, enzyme, transporter)[1][2][4].

Other names

PRPF39FLJ20666FLJ11128PRP39 homologpre-mRNA-processing factor 39 homologPRP39 pre-mRNA processing factor 39 homolog