Pre-mRNA processing factor 40 homolog A (PRPF40A)

Pre-mRNA processing factor 40 homolog A (PRPF40A) is a protein involved in the early steps of spliceosome assembly by mediating protein-protein interactions necessary for pre-mRNA splicing[1][3][4]. It functions as a scaffold, facilitating the bridge between 5' and 3' splice site recognition, and contains characteristic WW and FF domains that enable the binding of proline-rich motifs in splicing factors such as SF1 and SF3A1[1][4]. PRPF40A contributes to RNA binding, cytoskeleton organization, cell shape, migration, and cytokinesis, with additional roles in regulating alternative splicing and transcription[3][5]. It is associated with pathways and diseases involving mRNA processing defects, such as gastric cancer and Rett syndrome[3]. No drugs are currently known to target PRPF40A directly, nor is it established as a therapeutic target, but its roles in gene expression regulation and disease pathogenesis make it of biological interest[3][4][5].

Other names

FBP11FLAF1FNBP3HIP10HYPAHSPC225HIP-10FLJ20585NY-REN-6Prp40Fas ligand-associated factor 1Formin-binding protein 11Formin-binding protein 3Huntingtin yeast partner AHuntingtin-interacting protein 10Huntingtin-interacting protein ARenal carcinoma antigen NY-REN-6FBP-11