Pre-mRNA processing factor 40 homolog B (PRPF40B)

Pre-mRNA processing factor 40 homolog B (PRPF40B) is a human protein that acts as a splicing factor, associating with the U1 small nuclear ribonucleoprotein (snRNP) complex and interacting directly with SF1 and U2AF(65) proteins to facilitate the accurate assembly of spliceosomal machineries at pre-mRNA splice sites[1][2]. PRPF40B helps modulate alternative splicing, especially repressing exon inclusion for weak splice sites and regulating genes critical for cell survival and apoptosis, such as Fas[1][2]. Loss of PRPF40B disrupts normal alternative splicing patterns, induces apoptosis, and alters expression of genes involved in iron metabolism, hypoxia, and cholesterol biosynthesis—implicated in certain cancers, including acute myeloid leukemia and myelodysplastic syndrome[2][3]. PRPF40B does not contain an RNA recognition motif but functions through interactions mediated by WW and FF domains[2]. There are currently no drugs or therapeutic biologics developed to target PRPF40B directly.

Other names

PRP40 pre-mRNA processing factor 40 homolog BHuntingtin-interacting protein CHuntingtin yeast partner CHYPCPre-mRNA-processing factor 40 homolog BPRPF40B