Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Pre-mRNA-splicing factor 38B (PRPF38B)
- Target
- PRPF38B
- Molecular classification
- Other (splicing factor), RNA-binding protein
01
Overview
Pre-mRNA-splicing factor 38B (PRPF38B) is a protein-coding gene located on chromosome 1 that encodes an RNA-binding protein involved in the essential process of pre-mRNA splicing as part of the spliceosome complex, specifically the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle. It is primarily localized in the cell nucleus and participates in the maturation of pre-mRNAs, thereby controlling gene expression at the RNA processing level. Changes in PRPF38B expression and subcellular localization have been observed in cancer, particularly breast cancer, where it may be a prognostic biomarker, but there is no evidence it directly serves as a therapeutic drug target at this time.
- Other names
- NET1FLJ10330Sarcoma antigen NY-SAR-27PRP38 pre-mRNA processing factor 38 domain containing B
02
Biological functions
mRNA splicingRNA bindingpre-mRNA processing via the spliceosome
03
Disease associations
Cancer (including breast cancer, pancreatic ductal adenocarcinoma, sarcoma)Dilated cardiomyopathyType 1 diabetes mellitusUlceroglandular tularemia
04
Biomarkers
PRPF38B expression and localization (nuclear versus membranous) serve as candidate prognostic and predictive biomarkers in breast cancer, particularly in HER2-positive and ER-negative tumors
Beyond the preview
Go deeper on Pre-mRNA-splicing factor 38B (PRPF38B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pre-mRNA-splicing factor 38B (PRPF38B).