Precursor microRNA-155 (pre-miR-155)

Precursor microRNA-155 (pre-miR-155) is a non-coding RNA molecule that is processed into mature miR-155, a potent regulator of the immune system and hematopoiesis. It is derived from the B-cell integration cluster (BIC) gene and plays a critical role in the differentiation and function of B-cells, T-cells, and myeloid cells by silencing target mRNAs such as SHIP1 and SOCS1 (Source: PubMed, PMID: 27633453). Overexpression of miR-155 is strongly associated with various malignancies, particularly B-cell lymphomas and leukemias, as well as chronic inflammatory and autoimmune diseases (Source: NIH, Gene ID: 406947). As a therapeutic target, miR-155 is addressed using antisense oligonucleotides like Cobomarsen, which aim to inhibit its oncogenic or pro-inflammatory activity. These therapies are currently being evaluated in clinical trials for cutaneous T-cell lymphoma and other hematologic cancers (Source: ClinicalTrials.gov, NCT03713320). Understanding the regulation of pre-miR-155 processing is essential for developing precise interventions that can modulate its levels in a disease-specific manner.

Other names

MIR155B-cell integration clusterBIChsa-mir-155MicroRNA 155

Antisense oligonucleotides (antimiRs) bind to the mature or precursor microRNA-155 sequence through complementary base pairing, leading to its sequestration or degradation and preventing it from silencing its target messenger RNAs (mRNAs).