Preferentially expressed antigen in melanoma pseudogene

Preferentially expressed antigen in melanoma pseudogene (ENSG00000231590) is a genomic sequence in humans that closely resembles the protein-coding PRAME gene but does not encode a functional protein. Pseudogenes typically arise following gene duplications or retrotransposition events and are considered nonfunctional due to mutations, lack of regulatory elements, or incomplete sequence. There is no evidence that this pseudogene is expressed, codes for a protein, or has a direct biological or disease role. Its existence is of potential interest for genomic evolution or bioinformatics, but not for drug development, biomarker applications, or basic biology at this time.