Prefoldin subunit 3 (PFDN3)

Prefoldin subunit 3 (PFDN3), also known as VHL binding protein 1 (VBP1), is a component of the hexameric prefoldin complex, which acts as a molecular chaperone assisting the folding of newly synthesized polypeptides, particularly tubulin and actin[2][3]. PFDN3 was originally identified as a binding partner of the von Hippel-Lindau protein (pVHL), a tumor suppressor whose loss or mutation causes VHL disease and several types of cancer, including renal cell carcinoma[1][2][4]. The interaction between PFDN3 and pVHL is essential for stabilizing pVHL and preventing its aggregation and degradation[1][2]. Low levels of PFDN3 correlate with poor survival in kidney cancer patients with VHL gene mutations[1][2]. While PFDN3 is biologically important for cancer pathogenesis via its support of pVHL folding and stability, it is not currently considered a direct therapeutic target or receptor for drugs[1][2][4].

Other names

VHL binding protein 1VBP1PFDN3Prefoldin 3PFD3VBP-1von Hippel-Lindau-binding protein 1HIBBJ46Prefoldin subunit 3von Hippel-Lindau binding protein 1

Not applicable; no known drugs directly target Prefoldin subunit 3 or VBP1.