Prefoldin subunit 4 pseudogene

The prefoldin subunit 4 pseudogene (ENSG00000264289) is a genomic locus in humans that resembles the gene encoding prefoldin subunit 4 but contains disabling mutations likely rendering it nonfunctional at the protein level. Pseudogenes are considered "dead genes" as they arise from duplication or retrotransposition events, followed by accumulation of mutations such as insertions, deletions, or frameshifts, which prevent proper protein formation[3][5]. Although some pseudogenes can exert regulatory effects through their RNA transcripts, such roles require specific demonstration and are not reported for this locus. This gene is not a recognized therapeutic target and is not commonly included in drug discovery or biomarker panels[3][4][2]. This entry has been marked as **is_incorrect: true** because pseudogenes generally are not valid molecular targets for therapeutics unless there is specific evidence of their biological or clinical significance, which is lacking here.