Target intelligence / Profile preview

Prefrontal cortex (PFC)

Target: PFC
Molecular classification: Other (brain region)

Overview

The prefrontal cortex is a region in the frontal lobe of the brain involved in executive functions, decision making, working memory, and social behavior. It plays a crucial role in personality expression and emotional regulation. The prefrontal cortex is divided into several subregions, each with distinct functions and connections to other brain areas. It is not a specific molecular target for drugs but is affected by various neurological and psychiatric conditions.

Other names: Frontal association cortexPrefrontal lobe

Mechanism of action

Not applicable as it is a brain region rather than a specific molecular target.

Biological functions

Executive functionsDecision makingWorking memoryPersonality expressionSocial cognitionEmotional regulationPlanningProblem-solving

Disease associations

Neurodegenerative diseasePsychiatric disordersCognitive disordersAddiction

Safety considerations

Damage or dysfunction in the prefrontal cortex can lead to significant cognitive and behavioral impairments.

Interacting drugs

Psychostimulants

2 more in the full profile.

Biomarkers

Cognitive performance testsNeuroimaging markers

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