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Target intelligence / Profile preview
Pregnancy-specific beta-1-glycoprotein 11 (PSG11)
- Target
- PSG11
- Molecular classification
- Immunoglobulin superfamily, Carcinoembryonic antigen family (CEA family), Not a receptor, enzyme, transporter, or classic signaling target[5][6]
01
Overview
Pregnancy-specific beta-1-glycoprotein 11 (PSG11) is one of several highly glycosylated proteins primarily produced by the placental syncytiotrophoblast during pregnancy[5][6]. PSG11 belongs to the immunoglobulin superfamily and is a member of the carcinoembryonic antigen family (CEA/PSG), which functions mainly as immunomodulators helping protect the fetus by modulating maternal immune responses[1][5][6]. PSGs as a family have also been implicated in promoting angiogenesis at the maternal-fetal interface and regulating trophoblast function, but most research focuses on the closely related PSG1, with specific functional studies on PSG11 lacking. Abnormal PSG expression has been linked to pregnancy disorders; PSG11 variants may be associated with conditions such as Rh isoimmunization and gestational choriocarcinoma[5]. There are no known drugs targeting PSG11 and no established usage as a therapeutic target or a clinical biomarker distinct from other PSGs.
- Other names
- Pregnancy-specific glycoprotein 11PSBG-11Pregnancy-specific beta-1-glycoprotein 13PSG13PSBG-13PSG14MGC22484PS-beta-G-11PS-beta-G-13
02
Biological functions
Immunomodulation during pregnancyPotential regulation of angiogenesisLikely contributes to establishment/maintenance of maternal-fetal tolerance[1][5][6]
03
Disease associations
Implicated in pregnancy-associated disordersPossible association: Rh isoimmunization, gestational choriocarcinoma[5]
04
Biomarkers
Potential pregnancy biomarker (based on PSG family use; PSG1 is used clinically, no specific evidence for PSG11 as clinical biomarker)[4][5]
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