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Target intelligence / Profile preview
Pregnancy-specific beta-1-glycoprotein 7 (PSG7)
- Target
- PSG7
- Molecular classification
- Other (Immunoglobulin superfamily; Carcinoembryonic antigen family; Pregnancy-specific glycoproteins)
01
Overview
Pregnancy-specific beta-1-glycoprotein 7 (PSG7) is a member of the pregnancy-specific glycoprotein family, itself part of the carcinoembryonic antigen (CEA) gene family within the immunoglobulin superfamily. PSG7 is predominantly expressed by placental trophoblasts and released into the maternal circulation during pregnancy; its primary proposed role is supporting the maintenance of a normal pregnancy, likely through immunomodulatory functions at the maternal-fetal interface. Clinical associations include gestational trophoblastic neoplasms and certain pregnancy complications, and PSG7, like other PSG proteins, may be relevant as a biomarker for placental function. However, PSG7 is not known to be a direct therapeutic target, nor is it a canonical receptor, enzyme, or transporter.
- Other names
- PS-beta-G-7PSBG-7PSG1PSGGApregnancy-specific glycoprotein 7putative pregnancy-specific beta-1-glycoprotein 7
02
Biological functions
Maintenance of normal pregnancyImmunomodulation during pregnancyCell surface interactions at the vascular wall
03
Disease associations
Gestational choriocarcinomaGestational trophoblastic diseaseOther disorders related to placental function
04
Biomarkers
potential biomarker for placental function and pregnancy status
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