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Pregnane Glycosides
- Molecular classification
- Natural Product, Steroid, Glycoside
01
Overview
Pregnane glycosides are a class of naturally occurring steroidal glycosides characterized by a pregnane (C21) skeleton linked to one or more sugar moieties. They are found in plants, particularly in the Apocynaceae and Asclepiadaceae families. These compounds exhibit a wide range of pharmacological activities including antidiabetic, anti-obesity, anti-inflammatory, and antibacterial effects. Their mechanism of action includes appetite suppression via CNS modulation and inhibition of adrenal steroidogenesis.
- Other names
- Steroidal GlycosidesC21 Glycosides
02
Mechanism of action
Appetite suppression via CNS modulation; inhibition of adrenal steroidogenesis by interfering with steroidogenic enzymes like CYP11B1 and downregulating HSD3B2 mRNA, leading to decreased androstenedione/corticosterone/cortisol production.
03
Biological functions
Modulation of food intakeInhibition of steroidogenesisAnti-diabetic activityAnti-obesity activityAnti-inflammatory activityAnti-nociceptive activityAntiulcer activityAntibacterial activityImmunomodulatory activityHypolipidemic activity
04
Disease associations
DiabetesObesityInflammationPainUlcersInfectionHyperlipidemia
05
Safety considerations
Potential for adrenal dysfunction due to steroidogenesis inhibitionUnknown long-term effects
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