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Plasma Kallikrein (KLKB1)
- Target
- KLKB1
- Molecular classification
- Serine Protease, Enzyme
01
Overview
Plasma kallikrein is a serine protease that plays a critical role in blood coagulation, fibrinolysis, and the kinin system. It is produced from prekallikrein by factor XIIa. Plasma kallikrein cleaves high-molecular-weight kininogen (HMWK) to release bradykinin, a potent vasodilator and mediator of inflammation. As a therapeutic target, inhibiting plasma kallikrein can reduce bradykinin production, which is beneficial in treating angioedema and other inflammatory conditions. Conversely, enhancing its activity could promote fibrinolysis and prevent thrombosis, but with potential bleeding risks.
- Other names
- PrekallikreinFletcher factor
02
Mechanism of action
Inhibition of serine protease activity, preventing cleavage of HMWK and subsequent bradykinin release; disruption of contact activation pathway.
03
Biological functions
Blood coagulationFibrinolysisKinin generationInflammation modulationVasodilation
04
Disease associations
Cardiovascular diseaseInflammationHypertensionAngioedemaThrombosis
05
Safety considerations
Potential for bleeding complications if inhibiting coagulation too stronglyRisk of hypotension due to bradykinin inhibition or altered kinin regulationParadoxical thrombosis under certain conditions
06
Biomarkers
Prekallikrein levels (diagnostic for deficiency)Bradykinin levels (monitoring kinin system activation)
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