PRELI domain containing protein 3A (PRELID3A)

PRELI domain containing protein 3A (PRELID3A) is a mitochondrial lipid transfer protein that enables the transfer of phosphatidic acid (PA) between membranes, particularly across the mitochondrial intermembrane space[1][3][4][5][10]. By forming a complex with the partner protein TRIAP1, PRELID3A facilitates the critical import of phosphatidic acid required for cardiolipin synthesis in the mitochondrial inner membrane[4][8]. Structural studies demonstrate that the PRELI domain forms a lipid-binding cavity that is essential for regulated lipid transfer[2][6]. PRELID3A localizes to the mitochondria and is essential for maintaining mitochondrial membrane structure and integrity through its role in phospholipid transport[2][4][8][10]. No direct information on clinically approved drugs, disease biomarker roles, or known safety concerns is available in current references; PRELID3A is primarily a fundamental component of mitochondrial lipid metabolism rather than a conventional therapeutic target[2][4].

Other names

PRELI domain containing 3AC18orf43SLMO1HFL-EDDG1FLJ31484Protein slowmo homolog 1erythroid differentiation and denucleation factor 1