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Premature Stop Codon Readthrough (None)

Target: None
Molecular classification: Other

Overview

Premature stop codon readthrough refers to the process by which the ribosome bypasses a premature termination codon (PTC) during translation, allowing for continued protein synthesis and potentially restoring full-length, functional protein in cases where a nonsense mutation would otherwise truncate it. This phenomenon can occur naturally at low frequencies or be induced pharmacologically or genetically as a therapeutic strategy for genetic diseases caused by nonsense mutations.

Mechanism of action

Promotes near-cognate tRNA binding at premature stop codons, allowing translation to continue.

Biological functions

Translation elongationTranslation terminationProtein synthesis

Disease associations

Genetic diseases caused by nonsense mutations

Safety considerations

Off-target effects on normal termination eventsGlobal suppression of proper translational termination

Interacting drugs

Gentamicin

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