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Preproinsulin peptide presented by HLA-A*02:01
- Molecular classification
- Peptide-MHC complex, MHC Class I molecule, Peptide antigen
01
Overview
The presentation of a preproinsulin-derived peptide by the HLA-A*02:01 MHC class I molecule. This complex is recognized by CD8+ T cells and plays a role in the autoimmune response observed in type 1 diabetes. An example peptide is ALWGPDPAAA (residues 15-24).
- Other names
- HLA-A*02:01-restricted preproinsulin peptidePreproinsulin/HLA-A*02:01 complexpPPI/HLA-A*02:01
02
Biological functions
Antigen presentationT cell activationImmune surveillanceAutoimmunity
03
Disease associations
Type 1 diabetes mellitusAutoimmune disease
04
Safety considerations
Potential for off-target effects in immunotherapyRisk of autoimmune exacerbation
05
Biomarkers
T cell reactivity to preproinsulin/HLA-A*02:01Presence of preproinsulin-specific CD8+ T cells
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