Prevention of protein loss

The term "Prevention of protein loss” broadly refers to cellular mechanisms that stabilize, fold, or prevent the degradation or aggregation of proteins, ensuring that proteins maintain their correct structure and function over time. These mechanisms are collectively known as the proteostasis network and include processes such as regulated protein synthesis, molecular chaperone-mediated folding, the ubiquitin-proteasome system for targeted protein degradation, and autophagy-lysosome pathways for bulk degradation of proteins and organelles[3][4][1][2]. Maintenance of proteostasis is crucial for cellular health, stress resistance, aging, and prevention of various diseases including neurodegenerative diseases, cancer, and metabolic disorders. Disruption or failure of these systems can lead to pathological protein aggregation, loss-of-function states, and tissue dysfunction.

Other names

Maintenance of protein homeostasisProteostasisProtein quality control