Prickle planar cell polarity protein 1 (PRICKLE1)

Prickle planar cell polarity protein 1 (PRICKLE1) is a protein encoded by the PRICKLE1 gene in humans. It is involved in the planar cell polarity pathway, which is crucial for controlling the organization and movement of cells during development. PRICKLE1 functions as a negative regulator of the canonical Wnt/beta-catenin signaling pathway and plays a role in the localization and trafficking of transcriptional repressors such as REST/NRSF. The protein is essential for proper nervous system development, specifically for neuronal migration and cell polarity, and is required for normal limb and neural tube development. Mutations in PRICKLE1 are linked to progressive myoclonus epilepsy and associated neurological symptoms, highlighting its critical role in neurodevelopment[1][2][3][4]. Note: - PRICKLE1 is not a classical therapeutic target such as an enzyme, receptor, transporter, or ion channel, thus "is_target: false". - There are currently no known small molecule drugs or approved therapeutics that directly target PRICKLE1, so "interacting_drugs", "mechanism_of_action", and "biomarkers" are returned as null[3].

Other names

Prickle-like protein 1prickle homolog 1RILPFLJ31937EPM1BREST/NRSF-interacting LIM domain proteinREST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain proteinprickle-like 1PRIC1_HUMANFLJ31627MGC138902MGC138903