PRICKLE1 pseudogene 1 (PRICKLE1P1)

PRICKLE1 pseudogene 1 (PRICKLE1P1) is a pseudogene located on human chromosome 3, homologous to the functional PRICKLE1 gene, which encodes prickle planar cell polarity protein 1[2][3]. Pseudogenes such as PRICKLE1P1 do not produce functional proteins and are not considered therapeutically relevant targets, nor are they involved in known biological processes or human diseases. In contrast, the protein-coding gene PRICKLE1 is implicated in the development of the nervous system and participates in noncanonical Wnt/planar cell polarity signaling, impacting cell polarity and neuronal migration[1][3][6]. Only the protein-coding PRICKLE1 gene is associated with disease phenotypes such as progressive myoclonus epilepsy with ataxia, whereas the pseudogene PRICKLE1P1 lacks these functional impacts. Clarification: - *PRICKLE1P1* is **not a drug target** and is **not the same as PRICKLE1**, the protein-coding gene involved in nervous system development and certain neurological disorders. - The presence of "pseudogene" indicates **non-functionality**: PRICKLE1P1 does not produce a functional protein; thus, it is not considered a receptor, enzyme, transporter, or other molecular target of therapeutic relevance[2][3]. - Queries about targets or therapeutic relevance should focus on the **protein-coding PRICKLE1 gene**, not its pseudogene.

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