PRICKLE2 antisense RNA 1 (PRICKLE2-AS1)

PRICKLE2 antisense RNA 1 (PRICKLE2-AS1) is a human long non-coding RNA (lncRNA), meaning it is transcribed from the genome but does not encode a protein[1][5][6]. It is located on chromosome 3 (chr3:64024107-64103131, hg38)[1]. PRICKLE2-AS1 has been associated with epigenetic and transcriptional regulation through differential methylation patterns, particularly in certain cancers such as vulvar squamous cell carcinoma[4]. There are currently no known direct interacting drugs or established therapeutic targeting mechanisms for PRICKLE2-AS1, and it is not classified as a canonical therapeutic target such as a receptor, enzyme, transporter, or similar protein[1][5]. The main functional roles and disease associations are currently inferred from its encoded gene's expression profiles and observed differential methylation, suggesting a potential but as yet uncharacterized role in gene regulation and disease[2][4]. There is no evidence for PRICKLE2-AS1 being a misannotated or incorrect target—it is a valid lncRNA gene with supporting genomic and functional association data[1][5][6].

Other names

PRICKLE2 antisense RNA 1 (non-protein coding)PRICKLE2-AS1LINC00994