PRICKLE2 antisense RNA 2 (PRICKLE2-AS2)

PRICKLE2 antisense RNA 2 (PRICKLE2-AS2) is a long non-coding RNA gene mapped to human chromosome 3[1][5]. Antisense RNAs are often implicated in the regulation of their sense gene targets by mechanisms such as transcriptional interference, RNA-DNA interactions, or modulation of chromatin state. There are no published reports describing PRICKLE2-AS2 as a therapeutic target, or outlining a clear biological function, molecular pathway, or disease role. Its annotation is based on database records (e.g., Ensembl, BioGPS), but its functional characterization remains unreported in the scientific literature[1][5]. PRICKLE2-AS2 should not be confused with PRICKLE2, which is a protein-coding gene with well-established roles in neuronal function and has been linked to epilepsy and autism spectrum disorder[3][4]. The abbreviation “PRICKLE2-AS2” correctly refers to the antisense RNA and not to the PRICKLE2 protein. No drugs, mechanisms, or biomarkers associated, and no reports describing this antisense RNA as a target or marker in clinical or preclinical studies. The entry is not a classical receptor, enzyme, transporter, transcription factor, ion channel, or any target class used in pharmacology.

Other names

PRICKLE2-AS2