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Target intelligence / Profile preview
Primary microRNA 17–92 transcript
- Molecular classification
- Non-coding RNA, microRNA precursor
01
Overview
The primary microRNA 17–92 transcript (pri-miR-17-92) is a long, non-coding RNA precursor for the miR-17-92 cluster, encoding six microRNAs. It plays roles in development, cell proliferation, and cancer. Transcription is regulated by c-MYC and E2Fs. Mature miRNAs derived from pri-miR-17-92 promote cell cycle progression, inhibit apoptosis, and regulate differentiation. Dysregulation, especially overexpression, is linked to oncogenesis.
02
Mechanism of action
miRNAs regulate gene expression by binding to the 3'UTR of target mRNAs, leading to translational repression or mRNA degradation.
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Biological functions
Cell cycle progressionAnti-apoptosisDevelopmental regulation
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Disease associations
Cancer
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Safety considerations
Overexpression is associated with oncogenesis.
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Biomarkers
miR-17miR-18amiR-19amiR-20amiR-19b-1miR-92a-1
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