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Target intelligence / Profile preview
PRKCZ antisense RNA 1 (PRKCZ-AS1)
- Target
- PRKCZ-AS1
- Molecular classification
- Other (long non-coding RNA)
01
Overview
PRKCZ antisense RNA 1 (PRKCZ-AS1) is a long non-coding RNA implicated in lung adenocarcinoma where its expression is significantly upregulated in tumor tissues and cell lines. Knockdown experiments show that PRKCZ-AS1 promotes proliferation and migration, and inhibits apoptosis in cancer cells. Mechanistically, PRKCZ-AS1 acts as a competing endogenous RNA (ceRNA) by binding and sequestering miR-766-5p, leading to upregulated MAPK1 expression, a pathway that enhances oncogenic processes in lung adenocarcinoma. Its aberrant regulation is associated with cancer biology, but PRKCZ-AS1 is not currently targeted by any known drugs. It may serve as a disease biomarker, but further validation is required for clinical use.
- Other names
- RP11-181G12.2PRKCZ-AS1
02
Mechanism of action
Not drug-targeted; biological mechanism is the sponging of miR-766-5p to regulate MAPK1 gene expression
03
Biological functions
Regulation of cell proliferationRegulation of cell migrationApoptosis modulationMicroRNA sponging (ceRNA function)
04
Disease associations
Cancer (notably lung adenocarcinoma)
05
Biomarkers
Elevated expression in lung adenocarcinoma tissues and cell lines may be a biomarker for disease presence or progression
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