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PRKG1 antisense RNA 1 (PRKG1-AS1)

Target: PRKG1-AS1
Molecular classification: Long non-coding RNA (lncRNA), Other (not a protein, receptor, or enzyme)

Overview

PRKG1 antisense RNA 1 (PRKG1-AS1) is a long non-coding RNA predominantly localized in the cell nucleus, which regulates the adjacent DKK1 gene through epigenetic processes including methylation and modulation of EZH2 protein. PRKG1-AS1 is implicated in cancer biology: its overexpression promotes cell proliferation, migration, and poor prognosis in lung adenocarcinoma, while in gastric cancer, it interacts with another lncRNA, UC.145, and helps determine cancer cell signaling output via DKK1 and Wnt signaling pathways. Knockdown of PRKG1-AS1 reduces cell migration, proliferation, and apoptosis rates in vitro, revealing its function in controlling cell fate decisions relevant to oncogenesis. PRKG1-AS1 is currently studied as a prognostic biomarker in cancers but is not directly targeted by approved medicines or experimental drugs as of date.

Other names: PRKG1-AS1RP11-573I11.2

Biological functions

Regulation of gene expression (regulates DKK1 expression at transcript and epigenetic levels)Epigenetic modulation (interacts with UC.145 and mediates methylation mechanism affecting DKK1 and EZH2)Cell proliferation (promotes proliferation and metastasis in lung adenocarcinoma)Modulation of apoptosis (knockdown decreases apoptosis)

Disease associations

Cancer (regulates prognosis and cellular behavior in gastric cancer and lung adenocarcinoma)Noted association as a biomarker for unfavorable prognosis in cancer patients

Biomarkers

PRKG1-AS1 expression itself (considered as a biomarker for poor prognosis in lung adenocarcinoma and possibly gastric cancer)DKK1 (co-expressed and regulated; its expression is tightly linked to PRKG1-AS1)

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