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Target intelligence / Profile preview
PRKR-interacting protein 1 (PRKRIP1)
- Target
- PRKRIP1
- Molecular classification
- Other (spliceosome-associated protein), RNA-binding protein
01
Overview
PRKR-interacting protein 1 (PRKRIP1) is a spliceosome-associated protein required for pre-mRNA splicing and is involved in RNA processing in human cells[3][4][8]. It binds double-stranded RNA, interacts with protein kinases, and can inhibit EIF2AK2 (protein kinase R) activity[3][8]. PRKRIP1 is located in human chromosome 7 and has functions in chromatin organization and synaptic function within specific tissues[2]. It is recognized as a marker of poor prognosis in colorectal cancer but is not established as a direct therapeutic target or druggable receptor/enzyme[7][3][8].
- Other names
- PRKR interacting protein 1C114FLJ13902KRBOX3KRAB box domain containing 3likely ortholog of mouse C114 dsRNA-binding proteinPRKRIP1 (IL11 inducible)
02
Biological functions
pre-mRNA splicingdouble-stranded RNA bindingprotein kinase bindingprotein kinase inhibition
03
Disease associations
Other (reported marker of poor prognosis in colorectal cancer, associated with fructose-1,6-bisphosphatase deficiency)
04
Biomarkers
Marker of poor prognosis in colorectal cancer[7]
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