PRMT5 antisense RNA 1 (PRMT5-AS1)

PRMT5 antisense RNA 1 (PRMT5-AS1) is a human long noncoding RNA gene (lncRNA), formally named PRMT5 antisense RNA 1, and indexed as LOC124903285 in databases[4]. It is transcribed from the region antisense to the PRMT5 gene, but does **not encode a protein** and is classified as a non-protein-coding RNA. Although the PRMT5 protein itself is an important type II arginine methyltransferase with diverse biological functions in chromatin modification and gene regulation[1][3][5], PRMT5-AS1 is simply the RNA transcript oriented antisense to PRMT5 and is *not* considered a therapeutic target, receptor, enzyme, or transporter. There is insufficient evidence in major databases or scientific literature for PRMT5-AS1 to be a direct therapeutic target, nor are there any reported interacting drugs, approved biomarkers, or safety concerns specific to PRMT5-AS1[4]. Its biological function is most likely in post-transcriptional regulation of PRMT5 or related genes but is not yet clearly established. **Clarifications and notes:** - The confusion may arise because *PRMT5* (the protein) is an important methyltransferase therapeutic target, while *PRMT5-AS1* is its antisense RNA and *not* the same entity[1][3][5]. - If a therapeutic target is intended, PRMT5 (Protein arginine methyltransferase 5) should be referenced, not PRMT5-AS1. - Current evidence does **not support PRMT5-AS1 as a classical therapeutic target**; it is a noncoding gene with no direct pharmacological targeting[4]. If you are seeking information about PRMT5 protein, please clarify, as most drug development and disease roles concern the methyltransferase enzyme PRMT5, and not its antisense RNA transcript.

Other names

PRMT5 antisense RNA 1 (non-protein coding)PRMT5-AS1LOC124903285